Commented University Calendar

Chromatographic Separation Processes

Course Units (new window)

Instructor:

Privatdoz. Dr. habil. Monika Johannsen

Course Format:

2 Hours Lecture

Period:

Winter Semester

Language:

English

Recommended Previous Knowledge:

Fundamentals of Chemistry, Fluid Process Engineering, Thermal Separation Processes, Chemical Engineering, Chemical Engineering, Bioprocess Engineering - Fundamentals

Contents:

  • Introduction: overview, history of chromatography, LC (HPLC), GC, SFC
  • Fundamentals of linear (analytical) chromatography, retention time/factor, separation factor, peak resolution, band broadening, Van-Deemter equation
  • Fundamentals of nonlinear chromatography, discontinuous and continuous preparative chromatography (annular, true moving bed - TMB, simulated moving bed - SMB)
  • Adsorption equilibrium: experimental determination of adsorption isotherms and modeling
  • Equipment for chromatography, production and characterization of chromatographic adsorbents
  • Method development, scale up methods, process design, modeling of chromatographic processes, economic aspects
  • Applications: e.g. normal phase chromatography, reversed phase chromatography, hydrophobic interaction chromatography, chiral chromatography, bioaffinity chromatography, ion exchange chromatography

Learning Outcomes:

  • Classify chromatographic separation methods
  • Explain separation mechanisms in chromatography
  • Describe parameters for evaluation of chromatographic separations
  • Differentiate models for chromatography
  • Evaluate chromatographic processes regarding productivity, solvent consumption and profitability
  • Prepare a special scientific topic and its presentation and discussion

Reading Resources:

Guiochon, G.; Golshan-Shirazi, S.; Katti, A.M.: Fundamentals of Preparative and Nonlinear Chromatography. Boston, Academic Press (1994).

Guiochon, G.; Lin, B.: Modeling for Preparative Chromatography. Amsterdam, Elsevier (2003).

Ganetsos, G.; Barker, P.E.: Preparative and Production Scale Chromatography. New York: M. Dekker (1993).

Schmidt-Traub, H.; Preparative Chromatography of Fine Chemicals and Pharmaceutical Agents. Weinheim: Wiley-VCH (2005).

Performance Record:

Presence, oral presentation of original scientific article with written summary, written examination.

Workload:

60 hours total

Further Information:

http://www.tu-harburg.de/v8/lehre.html

Contact:

m.johannsen@tuhh.de

Credit points of this module can be found in the course plan for the corresponding course of study.

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