Commented University Calendar
Chromatographic Separation Processes
Privatdoz. Dr. habil. Monika Johannsen
2 Hours Lecture
Recommended Previous Knowledge:
Fundamentals of Chemistry, Fluid Process Engineering, Thermal Separation Processes, Chemical Engineering, Chemical Engineering, Bioprocess Engineering - Fundamentals
- Introduction: overview, history of chromatography, LC (HPLC), GC, SFC
- Fundamentals of linear (analytical) chromatography, retention time/factor, separation factor, peak resolution, band broadening, Van-Deemter equation
- Fundamentals of nonlinear chromatography, discontinuous and continuous preparative chromatography (annular, true moving bed - TMB, simulated moving bed - SMB)
- Adsorption equilibrium: experimental determination of adsorption isotherms and modeling
- Equipment for chromatography, production and characterization of chromatographic adsorbents
- Method development, scale up methods, process design, modeling of chromatographic processes, economic aspects
- Applications: e.g. normal phase chromatography, reversed phase chromatography, hydrophobic interaction chromatography, chiral chromatography, bioaffinity chromatography, ion exchange chromatography
- Classify chromatographic separation methods
- Explain separation mechanisms in chromatography
- Describe parameters for evaluation of chromatographic separations
- Differentiate models for chromatography
- Evaluate chromatographic processes regarding productivity, solvent consumption and profitability
- Prepare a special scientific topic and its presentation and discussion
Guiochon, G.; Golshan-Shirazi, S.; Katti, A.M.: Fundamentals of Preparative and Nonlinear Chromatography. Boston, Academic Press (1994).
Guiochon, G.; Lin, B.: Modeling for Preparative Chromatography. Amsterdam, Elsevier (2003).
Ganetsos, G.; Barker, P.E.: Preparative and Production Scale Chromatography. New York: M. Dekker (1993).
Schmidt-Traub, H.; Preparative Chromatography of Fine Chemicals and Pharmaceutical Agents. Weinheim: Wiley-VCH (2005).
Presence, oral presentation of original scientific article with written summary, written examination.
60 hours total
Credit points of this module can be found in the course plan for the corresponding course of study.